carbonyl fluoride inhalation

AMRL-TR-70-77. 2004. ACGIH (American Conference of Government and Industrial Hygienists). Exposure of rats to carbonyl fluoride at 310 ppm resulted in focal hemorrhage of the lungs and pulmonary edema, observed 24 h after exposure. No data regarding the carcinogenicity of carbonyl fluoride in humans were found. However exposure to carbonyl fluoride was generated via polytetrafluoroethylene pyrolysis; therefore, exposure included other pyrolysis products. Recent production data were not found. TABLE E-1 Data Used in the Category Plot for Carbonyl Fluoride. No human data relevant to developing AEGL-1 values for carbonyl fluoride were found. Rats exposed at 5 ppm exhibited dyspnea and cyanosis (DuPont 1956). At 5 ppm, the rats developed slight dyspnea and cyanosis. (1968a) reported that deaths usually occurred within 24 h of exposure with few latent deaths. Eighteen days after the last exposure, the urinary fluoride concentration was four times that of controls. Acute Exposure Guideline Levels; Contact Us. Carbonyl fluoride is structurally related to phosgene which was used as a chemical weapon during the First World War. The fluoride ion is readily absorbed into the bloodstream and is distributed to all organs. Pp 123-197 in Acute Exposure Guideline Levels for Selected Airborne Chemicals, Vol. The calculated LC50 was 34.3 ppm. The oxidation of carbon monoxide with silver difluoride is convenient: CO + 2 AgF 2 → COF Also, you can type in a page number and press Enter to go directly to that page in the book. It is a thermal decomposition product of fluoropolymers, such as polytetrafluoroethylene and polyfluoroethylenepropylene, heated at temperatures above 500°C. After 5 days of exposure (158 ppm-h plus 18 g of particulates), mortality was 22%; rats died during or shortly after exposure, and rats that died exhibited extreme malaise and weakness. DuPont de Nemours and Company, Inc.). Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, OH [online]. 2.3. Pyrolysis products are composed of a large number of compounds, can be of variable composition, and pose significant analytic challenges. Workers and residents in communities surrounding industrial facilities where these substances are manufactured, used, or stored and in communities along the nation's railways and highways are potentially at risk of being exposed to airborne EHSs during accidental releases or intentional releases by terrorists. [3] In the absence of chemical-specific data from which to derive an empirical value for the exponent n, default values of n = 3 when extrapolating to shorter durations and n = 1 when extrapolating to longer durations were used (NRC 2001). Propriétés physiques . DuPont (E.I. Contact FAN; FAN’s Accomplishments; FAN in the News; FAN Bulletins; Our Team; Tool Kit. The authors concluded that the toxic syndrome described in this study is compatible with the descriptions of hydrogen fluoride toxicity. Biochemical changes associated with toxic exposures to polytetrafluoroethylene pyrolysis products. Patocka, J., and J. Bajgar. Am. Assoc. Acute effects of 10-minute exposure to hydrogen fluoride in rats and derivation of a short-term exposure limit for humans. (0.52 ppm)1 × 240 min = 124.8 ppm-min. Hydrogen fluoride (CAS Reg. CAS No. The toxicity of polytetrafluoroethylene pyrolysis products – including carbonyl fluoride and a reaction product, silicon tetrafluoride. Data adequacy: Data on carbonyl fluoride were inadequate for deriving AEGL-2 values, so values were estimated by dividing the AEGL-3 values by 3. There are no human data available on carbonyl fluoride. 2011b. Available: http://www.cdc.gov/niosh/npg/npgd0103.html [accessed August 2013]. DuPont de Nemours and Company, Inc.). The AEGL-3 values for carbonyl fluoride were determined by using the BMCL05 of 5.2 ppm derived from the study by DuPont (1976) as the point-of-departure. A study by Scheel et al. The threshold limit value–time-weighted average for carbonyl fluoride was established by the American Conference of Governmental Industrial Hygienists (ACGIH) on the basis of data from Scheel et al. Whether portable gas detectors, gas detection tubes or personal protective equipment - Dräger offers a comprehensive portfolio to protect you when handling hazardous substances. J. * Carbonyl Fluoridecan affect you when breathed in and may be absorbed through the skin. DuPont (1956, 1959, and 1976) conducted studies of rats exposed to carbonyl fluoride for 2-4 h, but two of the studies reported only nominal concentrations, used relatively few animals, and reported few study details. (1968a, 1968b) exposed rats to carbonyl fluoride produced by burning polytetrafluoroethylene. Post-mortem lung fluoride concentrations and lung weights were measured, and gross pathology noted. Carbonyl fluoride was generated by polytetrafluoroethylene pyrolysis at 550ºC. Research at the IRSST + Research Priorities. NLM Scheel, L.D., W.C. Lane, and W.E. Available: http://www.cdc.gov/niosh/npg/npgd0108.html [accessed August 2013]. Inhalation If adverse effects occur, remove to uncontaminated area. Toxicology of Perfluoroisobutene. Share. Haskell Laboratory Report No. Details of the animal study of carbonyl fluoride (DuPont 1956) were insufficient to consider using it as a basis to derive AEGL-1 values. Absence of AEGL-1 values does not imply that exposures below the AEGL-2 values are without adverse effects. Urine was collected and analyzed for fluoride, tissues were collected and analyzed for inhibition of succinic dehydrogenase, and urine was analyzed for protein, glucose, ketones, and occult blood. In case of fire in the … Larkin. * Breathing Carbonyl Fluoridecan irritate the lungs causing coughing and/or shortness of breath. Scheel et al. Acute Inhalation Toxicity Studies of Hydrogen Fluoride and Carbonyl Fluoride. Methods: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF 2.Respiration was monitored before, during, and after exposure. 20(3): 247-255. TOXICOLOGICAL INFORMATION Pentafluoroethane (HFC-125) Inhalation 4 h LC50 : > 800000 ppm , Rat Inhalation No Observed Adverse Effect Concentration : 75000 ppm , Dog Cardiac sensitization Inhalation Low Observed Adverse Effect Concentration … No other information was reported. Rats exposed to carbonyl fluoride at 5 or 10 ppm for 4 h experienced dyspnea and rapid shallow respiration (DuPont 1956, 1959). HSDB (Hazardous Substances Data Bank). 1A H314 - Causes severe skin burns and eye damage Eye Dam. DuPont (1976) exposed male ChR-CD rats to carbonyl fluoride at 26.7, 30.8, 32.7, 41.3, 44.7, 47.2, or 47.6 ppm for 4 h. Deaths occurred at every concentration. Reprod Toxicol. (1968a) reported deep lung focal hemorrhage and edema in rats exposed for 1 h to carbonyl fluoride produced from polytetrafluoroethylene pyrolysis. Hydrogen fluoride. USA.gov. The primary mechanism of action of phosgene is acylation resulting in lipid and protein denaturation, irreversible membrane changes, and disruption of enzymatic function. OTS0571353. Although the AEGL values represent threshold concentrations for the general public, including susceptible subpopulations, such as infants, children, the elderly, persons with asthma, and those with other illnesses, it is recognized that individuals, subject to idiosyncratic responses, could experience the effects described at concentrations below the corresponding AEGL. The low concentration of 2.5 ppm was not lethal to the rats and no clinical signs developed. Am. The calculated BMC01 was 10.4 ppm and the BMCL05 was 5.2 ppm. This site needs JavaScript to work properly. C3 × 30 min = 33.74592 ppm-min Carbonyl fluoride is the fluorine analogue of phosgene (carbonyl chloride). On day 1 and 5 of the exposure period, and 3, 7, and 18 days postexposure urine samples were collected and examined for fluoride excretion and glucose, protein, and ketones. Varying LC50 values for rats have been reported: 4-h LC50 of 34.3 ppm (DuPont 1976), 90 ppm (Scheel et al. Available: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB [accessed August 2013]. Available: http://www.asanltr.com/ASANews-98/pfib.html [accessed August 2013]. Test species/Strain/Number: Rat; ChR-CD; 10/group, Exposure route/Concentrations/Durations: Inhalation; 26.7, 30.8, 32.7, 41.3, 44.7, 47.2, 47.6 ppm for 4 h. Effects: Rapid shallow respiration and pulmonary edema. Extremely hazardous substances can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars and trucks transporting EHSs. (0.52 ppm)3 × 240 min = 33.74592 ppm-min Haskell Laboratory Report No. In the absence of empirical data on carbonyl fluoride, the AEGL-2 values for carbonyl fluoride were set at one-third of the AEGL-3 values. J. An intraspecies uncertainty factor of 3 was applied because carbonyl fluoride is a direct-acting irritant of the lungs and its effects are not expected to differ greatly among individuals. Hydrogen Fluoride, Hydrogen Iodide, and Carbonyl Fluoride None of the exposure studies examined contained any reports of experimental measurements of any of these three chemicals, nor were the estimates of the possible exposure to them expected from various CF 3 I discharges. bREL-TWA (recommended exposure limit – time-weighted average, National Institute for Occupational Safety and Health) (NIOSH 2011a) is defined as the time-weighted average concentration for up to a 10-h workday during a 40-h workweek. Pp. The liver showed enlarged nuclei and fatty infiltration. Carbonyl fluoride is a strong irritant of the eyes and respiratory tract. Chemical and physical properties of carbonyl fluoride are presented in Table 2-2. Smith, and M.B. Colour : Colourless. J. C = 0.26 ppm, APPENDIX C However, the effects are not disabling and are transient and reversible upon cessation of exposure. No data on the developmental or reproductive toxicity of carbonyl fluoride were found. Morbidity and mortality resulting from acute inhalation exposures to hydrogen fluoride and carbonyl fluoride in rats. The AEGL-3 values for carbonyl fluoride were derived by using the BMCL05 (benchmark concentration, 95% lower confidence limit with 5% response) of 5.2 ppm from a study in rats (DuPont 1976) as the point-of-departure. Perry, W.G., F.A. Converting the LC50 for hydrogen fluoride to an equivalent concentration of carbonyl fluoride gives a predicted value of 680 ppm, nearly 50% greater than that observed. Mise à jour : 1987-12-18. Carbonyl fluoride is shipped as a liquefied compressed gas (NIOSH 2011a). About FAN. The data were presented in a table of a one-page preliminary report. The study by Scheel et al. The mechanism of action for carbonyl fluoride is unknown. Carbonyl fluoride agent detailed information in Haz-Map database. This report will inform planning, response, and prevention in the community, the workplace, transportation, the military, and the remediation of Superfund sites. NCI CPTC Antibody Characterization Program. 29(1):41-48. Rapid to convulsive respiration and pulmonary edema were observed in rats exposed to carbonyl fluoride for 4 h. Death occurred at all concentrations tested. Absence of an AEGL-1 value does not imply that exposures below the AEGL-2 … 1This document was prepared by the AEGL Development Team composed of Jennifer Rayner (Oak Ridge National Laboratory), Julie Klotzbach (SRC, Inc.), Chemical Manager Iris Camacho (National Advisory Committee [NAC] on Acute Exposure Guideline Levels for Hazardous Substances), and Ernest V. Falke (U.S. Environmental Protection Agency). DuPont, Haskell Laboratory, Newark, DE, Threshold for lethality; BMCL05 of 5.2 ppm, The concentration-exposure duration relationship for many irritant and systemically-acting vapors and gases may be described by, the relationship Cn × t = k, where the exponent n ranges from 0.8 to 3.5 (ten Berge et al. Washington, DC: National Academy Press. J. Share a link to this book page on your preferred social network or via email. 2010 Jan;29(1):1-9. doi: 10.1016/j.reprotox.2009.09.005. That procedure, based on guidance in NRC (2001), is applicable for chemicals with steep concentration-response curves. 1998 Jun;27(3):207-16. doi: 10.1006/rtph.1998.1203. The NAC reviewed and revised the document and AEGLs as deemed necessary. A latency period was not reported by DuPont (1976), but Scheel et al. DuPont (E.I. Standards and guidelines for carbonyl fluoride are presented in Table 2-8. DuPont de Nemours and Company, Inc.). Am. However, individual data and photomicrographs of the lungs were not provided for those species. Carbonyl fluoride can also be prepared by reaction of phosgene with hydrogen fluoride and the oxidation of carbon monoxide, although the latter tends to result in over-oxidation to carbon tetrafluoride. Liquefied gas H280 - Contains gas under pressure; may explode if heated Acute Tox. Its irritancy is hypothesized to be due to hydrogen fluoride, a known sensory irritant. Carbonyl fluoride: 300 ft: 0.4 mi: 1.4 mi: 2000 ft: 2.2 mi: 5.1 mi: Carbonyl fluoride, compressed: 300 ft: 0.4 mi: 1.4 mi: 2000 ft: 2.2 mi: 5.1 mi: The ERG doesn't predict that large amounts of toxic-by-inhalation gases will be produced if this material is spilled in water. bExposed rats to polytetrafluoroethylene pyrolysis products (550ºC) and reported concentrations of measured fluoride. 1998. Den Haag: SDU Uitgevers [online]. No other emergency standards such as emergency response planning guidelines or immediately dangerous to life and health values are available for carbonyl fluoride. AEGLs represent threshold exposure limits (exposure levels below which adverse health effects are not likely to occur) for the general public and are applicable to emergency exposures ranging from 10 minutes (min) to 8 h. Three levels - AEGL-1, AEGL-2, and AEGL-3 - are developed for each of five exposure periods (10 min, 30 min, 1 h, 4 h, and 8 h) and are distinguished by varying degrees of severity of toxic effects. Although the authors state that the exposures were to carbonyl fluoride at 50 ppm, the total exposure reported of 158 ppm-h and graphic data presented in the report indicate that successive daily exposures were at concentrations of 52, 43, 29, 25, and 9 ppm. of toxicity (DuPont 1956). Carbonyl fluoride Results - AEGL Program. Atmospheres were generated with a metered air stream into the exposure chamber, and concentrations were measured by the hydrolysable fluoride method. These experiments suggest that hydrolysis to HF cannot solely explain COF2 toxicity. Kamellia Nejati, Akram Hosseinian, Esmail Vessally, Ahmadreza Bekhradnia, Ladan Edjlali. P[response] = Background + (1-Background), where CumNorm(.) The investigators stated that those effects were produced at the same concentration in other species, including the dog, rabbit, guinea pig, and mouse, although individual data and photomicrographs of the lungs were not provided for those species. Substance information for UN 2417 - Carbonyl fluoride based on the Hazardous Materials Table (Title 49 CFR 172.101) to assist in preparing a risk assessment for … (1968a) provides some support for a factor of 3. Ind. The 4-h LC50 (lethal. Available: http://www.inchem.org/documents/icsc/icsc/eics1216.htm [accessed May 2013]. 1968a), and 100 ppm (DuPont 1959), and 1-h LC50s of 360 ppm and 460 ppm for 8-week-old and 24-week-old rats, respectively. NA - Indicates that this parameter has hit a bound implied by some inequality constraint and thus has no standard error. AEGL-1 values for carbonyl fluoride are not recommended because of insufficient data. Am … In the absence of chemical-specific data to derive an empirical value for n, default values of n = 3 for extrapolating to shorter durations and n = 1 for extrapolating to longer durations were used (NRC 2001). No deaths occurred in the groups exposed at lower concentrations. A colorless gas with a pungent odor. Dalbey W, Dunn B, Bannister R, Daughtrey W, Kirwin C, Reitman F, Wells M, Bruce J. J Toxicol Environ Health A. According to the standing operating procedures for deriving AEGL values (NRC 2001), AEGL-3 values may be divided by 3 to estimate AEGL-2 values. concentration, 50% lethality) was approximately 100 ppm. Hyg. NRC (National Research Council). 2012. Very toxic by inhalation. With increasing airborne concentrations above each AEGL, there is a progressive increase in the likelihood of occurrence and the severity of effects described for each corresponding AEGL. 8EHQ-1092-11415. Respiration in the rats varied directly with exposure concentration and ranged from rapid shallow breathing to convulsive respiration. Keywords: In the absence of chemical-specific data from which to derive an empirical value for the exponent n, default values of n = 3 for extrapolating to shorter durations and n = 1 for extrapolating to longer durations were used (NRC 2001). An interspecies uncertainty factor of 3 was applied because the toxicity of a direct-acting irritant is not expected to differ substantially among species. Mortalities in the respective groups were 5/10, 3/10, 3/10, 6/10, 8/10, 9/10, and 6/10. TABLE 2-3 Summary of Acute Inhalation Data in Laboratory Animals. 4449-4522 in Patty’s Industrial Hygiene and Toxicology, 4th Ed., Vol. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. American Conference of Government and Industrial Hygienists, Cincinnati, OH. TABLE 2-2 Chemical and Physical Properties of Carbonyl Fluoride, Carbon difluoride oxide; carbon fluoride oxide; carbonic difluoride; carbon oxyfluoride; carbonyl fluoride, difluoroformaldehyde; fluophosgene; fluoroformyl fluoride; fluorophosgene, Unstable in presence of water, very hygroscopic, 1 ppm = 2.7 mg/m3 DuPont, Haskell Laboratory, Newark, DE. TABLE 2-5 AEGL-3 Values for Carbonyl Fluoride, TABLE 2-6 AEGL Values for Carbonyl Fluoride, TABLE 2-7 AEGL Values for Phosgene and Hydrogen Fluoride, TABLE 2-8 Standards and Guidelines for Carbonyl Fluoride. Available: http://www.dtic.mil/dtic/tr/fulltext/u2/714694.pdf [accessed june 23, 2014]. AEGL-2 values are based on a three-fold reduction of the AEGL-3 values because experimental data were not available to empirically derive AEGL-2 values. The concentration-exposure duration relationship for many irritant and systemically acting vapors and gases may be described by the equation Cn × t = k, where the exponent ranges from 0.8 to 3.5 (ten Berge et al. NIOSH Pocket Guide to Chemical Hazards: Carbonyl Fluoride [online]. 485-76. The authors referenced work by Coleman et al. Concentration-time mortality response relationship of irritant and systemically acting vapours and gases. No concurrent exposure issues for carbonyl fluoride were identified. Carbonyl fluoride 353-50-4 (Final) 10 min 30 min 60 min 4 hr 8 hr; ppm: AEGL 1: NR: NR: NR: NR: NR: AEGL 2 0.35 0.35 0.28 0.17 0.087: AEGL 3 1.0 1.0 0.83 0.52 0.26: NR = Not recommended due to insufficient data.

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